对大鼠突变体“裸鼠”中胸腺依赖性免疫的研究。

Studies on the thymus-dependent immunity in the rat mutant "nude".

作者信息

Svendsen U G, Koch C, Werdelin O, Christiansen P

出版信息

Acta Pathol Microbiol Scand C. 1981 Aug;89(4):293-5. doi: 10.1111/j.1699-0463.1981.tb02702.x.

DOI:10.1111/j.1699-0463.1981.tb02702.x

Abstract

Different T-cell capacities in nude, athymic rats were tested. Spleen cells from nude rats were unable to give significant responses to Con A as could spleen cells from normal rats. No precipitating antibodies after immunization with chicken serum were observed in nude rats, although such antibodies were found in the haired rats. The experiments confirmed that the used stock of nude rats had a similar T-cell defect as the original Rowett strain of nude rats.

摘要

对无胸腺裸鼠的不同T细胞能力进行了测试。与正常大鼠的脾细胞不同，裸鼠的脾细胞对刀豆蛋白A无法产生显著反应。在用鸡血清免疫后，裸鼠未观察到沉淀抗体，而有毛大鼠中则发现了此类抗体。实验证实，所使用的裸鼠种群与原始罗维特品系的裸鼠具有相似的T细胞缺陷。