Some skeletogenic lesions with common calvarial manifestations.

The skull may mirror many systemic diseases or conditions. In fact, when gross and microscopic pathologic findings are confusing, proper analysis of the skull radiograph may lead to a more accurate and complete diagnosis. The article discusses some of the most common systemic diseases with skull or calvarial manifestations (fibrous dysplasia, hyperparathyroidism, histiocytosis X, Paget's disease, and anemias), with special attention to pathophysiology.