弥漫性伤害性抑制控制（DNIC）的行为模型：5-羟色氨酸的增强作用。
Behavioral model for diffuse noxious inhibitory controls (DNIC): potentiation by 5-hydroxytryptophan.
作者信息
Kraus E, Besson J M, Le Bars D
出版信息
Brain Res. 1982 Jan 14;231(2):461-5. doi: 10.1016/0006-8993(82)90384-5.
PMID:6976820
Abstract
The effects of the serotonin precursor 5-HTP, were determined in a behavioral DNIC paradigm (increase in vocalization threshold after intraperitoneal injection of the algogenic agent, phenylbenzoquinone). This counter-irritation phenomenon was strongly potentiated by 5-HTP, such potentiation being blocked by the 5-HT receptor blocker, cinanserin. These results are in keeping with those of our recent single unit work in dorsal horn convergent neurons.
摘要
在一种行为性的弥漫性伤害性抑制控制（DNIC）范式（腹腔注射致痛剂苯醌后发声阈值升高）中，测定了血清素前体5-羟色氨酸（5-HTP）的作用。这种反刺激现象被5-HTP强烈增强，而这种增强被5-羟色胺受体阻滞剂辛那色林所阻断。这些结果与我们最近在背角汇聚神经元上的单单位研究结果一致。
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