合成有机化合物针对活性位点丝氨酰残基对活化的因子II、VII、IX和X的抑制作用。
Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue.
作者信息
Van der Woerd-de Lange J A, van Dam-Mieras M C, Hemker H C
出版信息
Haemostasis. 1981;10(6):315-47. doi: 10.1159/000214417.
PMID:6976920
Abstract
A series of 53 organic chemicals belonging to the groups of organic phosphates, sulfonyl derivatives and carbamates were screened for their activity against the coagulation factors IIa (thrombin), VIIa, IXa and Xa. Relatively specific inhibitors for the factors IIa, VIIa and Xa were found.
摘要
对属于有机磷酸盐、磺酰基衍生物和氨基甲酸盐类的53种有机化学品进行了筛选，以检测它们对凝血因子IIa（凝血酶）、VIIa、IXa和Xa的活性。发现了对因子IIa、VIIa和Xa具有相对特异性的抑制剂。
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