Kuffer T, Kapanci Y
Schweiz Med Wochenschr. 1981 Dec 5;111(49):1908-11.
1119 pulmonary biopsies (two thirds open) have been performed in 108 patients with signs of diffuse interstitial disease of the lung. The results showed 29 cases of fibrosing alveolitis, 4 of granulomatous alveolitis, 8 of diffuse interstitial fibrosis, 12 of eosinophilic granuloma, 12 of pneumoconiosis, 16 of sarcoidosis, and 38 with other pulmonary lesions. Biopsy via thoracotomy is the best diagnostic technique, with a 97.4% yield; with transparietal biopsies the yield is 81% and with transbronchial biopsies 60%. Histology permits exact diagnosis in all pneumopathies except fibrosing alveolitis. In this case the pathologist guides the clinician's investigations towards a search for an allergic etiology.
对108例有弥漫性间质性肺疾病体征的患者进行了1119次肺活检（三分之二为开放性活检）。结果显示，有29例为纤维性肺泡炎，4例为肉芽肿性肺泡炎，8例为弥漫性间质纤维化，12例为嗜酸性肉芽肿，12例为尘肺，16例为结节病，38例有其他肺部病变。开胸活检是最佳诊断技术，阳性率为97.4%；经胸壁活检阳性率为81%，经支气管活检阳性率为60%。组织学检查能对除纤维性肺泡炎外的所有肺病做出准确诊断。在纤维性肺泡炎这种情况下，病理学家指导临床医生的检查以寻找过敏病因。
