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Induction of cytochrome P-450 in rat liver by the antibiotic troleandomycin: partial purificaton and properties of cytochrome P-450-troleandomycin metabolite complexes.

作者信息

Mansuy D, Delaforge M, LeProvost E, Flinois J P, Columelli S, Beaune P

出版信息

Biochem Biophys Res Commun. 1981 Dec 31;103(4):1201-8. doi: 10.1016/0006-291x(81)90250-3.

DOI:10.1016/0006-291x(81)90250-3
PMID:6977361
Abstract
摘要

相似文献

1
Induction of cytochrome P-450 in rat liver by the antibiotic troleandomycin: partial purificaton and properties of cytochrome P-450-troleandomycin metabolite complexes.抗生素三乙酰竹桃霉素对大鼠肝脏细胞色素P - 450的诱导作用：细胞色素P - 450 - 三乙酰竹桃霉素代谢物复合物的部分纯化及性质
Biochem Biophys Res Commun. 1981 Dec 31;103(4):1201-8. doi: 10.1016/0006-291x(81)90250-3.
2
The cytochrome P-450 metabolite complex derived from troleandomycin: properties in vitro and stability in vivo.由醋竹桃霉素衍生而来的细胞色素P - 450代谢物复合物：体外特性及体内稳定性
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3
Induction by triacetyloleandomycin and partial purification of a LM3 form of cytochrome P-450 from rabbit liver microsomes.
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4
Self-induction by oleandomycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. Comparison with troleandomycin.
J Pharmacol Exp Ther. 1982 Apr;221(1):215-21.
5
Inhibition of rat liver estrogen 2/4-hydroxylase activity by troleandomycin: comparison with erythromycin and roxithromycin.
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6
Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.曲古霉素代谢产物对细胞色素P - 450的灭活作用。谷胱甘肽的保护作用。
J Pharmacol Exp Ther. 1983 Mar;224(3):685-91.
7
Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p.鉴定大鼠肝脏中由大环内酯类抗生素诱导产生的细胞色素P-450为糖皮质激素反应性细胞色素P-450p。
Biochemistry. 1985 Apr 23;24(9):2171-8. doi: 10.1021/bi00330a010.
8
Some erythromycin derivatives are strong inducers in rats of a cytochrome P-450 very similar to that induced by 16 alpha-pregnenolone carbonitrile.某些红霉素衍生物在大鼠体内是一种细胞色素P - 450的强诱导剂，该细胞色素P - 450与由16α - 孕烯醇酮腈诱导产生的细胞色素P - 450非常相似。
Biochem Biophys Res Commun. 1985 May 16;128(3):1434-9. doi: 10.1016/0006-291x(85)91100-3.
9
In vivo and in vitro effects of a new macrolide antibiotic roxithromycin on rat liver cytochrome P-450: comparison with troleandomycin and erythromycin.
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10
Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds.来自大环内酯类抗生素及相关化合物的细胞色素P450代谢中间复合物。
Methods Enzymol. 1991;206:559-73. doi: 10.1016/0076-6879(91)06126-n.

引用本文的文献

1
Evaluation of Strategies for the Assessment of Drug-Drug Interactions Involving Cytochrome P450 Enzymes.涉及细胞色素P450酶的药物相互作用评估策略的评价
Eur J Drug Metab Pharmacokinet. 2018 Dec;43(6):737-750. doi: 10.1007/s13318-018-0485-7.
2
Pharmacokinetic interactions of the macrolide antibiotics.大环内酯类抗生素的药代动力学相互作用。
Clin Pharmacokinet. 1985 Jan-Feb;10(1):63-79. doi: 10.2165/00003088-198510010-00003.