Snyder E L, Hezzey A, Barash P G, Palermo G
Transfusion. 1982 Jan-Feb;22(1):21-5. doi: 10.1046/j.1537-2995.1982.22182154209.x.
To determine the effect of microaggregate blood filtration on patients with compromised pulmonary function, we divided 50 patients having elective coronary bypass surgery into two groups. One group received all blood transfusions via a 170-micron standard filter (SF). The other group received blood through a 20-micron microaggregate blood filter (MF). Patients were monitored pre- and postoperatively for changes in arterial blood gases and cardiopulmonary function. Mean transfusion volume was seven units (SF) and six units (MF). Preoperatively, patients in both groups showed abnormal lung function with elevated intrapulmonary shunting (Qs/Qt) and alveolar-arterial gradients (A-aO2). Postoperatively, no significant differences (p greater than 0.05) were found between the groups for any of the tests of cardiopulmonary function evaluated. Posttransfusion, none of the patients in either group showed clinical signs of respiratory distress. We conclude that even for patients with some degree of pretransfusion pulmonary dysfunction, use of a microaggregate blood filter for six- to seven- unit transfusions does not provide significant clinical benefit.
为了确定微聚体血液滤过对肺功能受损患者的影响，我们将50例行择期冠状动脉搭桥手术的患者分为两组。一组通过170微米的标准滤器（SF）接受所有输血。另一组通过20微米的微聚体血液滤器（MF）接受输血。对患者在术前和术后监测动脉血气和心肺功能的变化。平均输血量为7单位（SF组）和6单位（MF组）。术前，两组患者均表现出肺功能异常，肺内分流（Qs/Qt）和肺泡-动脉氧分压差（A-aO2）升高。术后，在评估的任何心肺功能测试中，两组之间均未发现显著差异（p>0.05）。输血后，两组患者均未出现呼吸窘迫的临床体征。我们得出结论，即使对于输血前有一定程度肺功能障碍的患者，使用微聚体血液滤器进行6至7单位的输血也不会带来显著的临床益处。
