Obara N
Dev Comp Immunol. 1982 Winter;6(1):95-104. doi: 10.1016/0145-305x(82)90011-8.
Non-thymectomized and early-thymectomized Xenopus laevis were injected with 3H-thymidine, and labelled lymphocytes from thymus, spleen, and peripheral blood were transferred to histocompatible recipients to study their distribution by autoradiography. An extremely high proportion of labelled thymocytes was localized in the splenic red pulp of both non-thymectomized and thymectomized recipients after transfer. Labelled splenic lymphocytes were localized in a significantly higher density in the splenic white- than red pulp, particularly 24 hr after cell transfer. This preference of labelled lymphocytes in the white pulp was more evident when early-thymectomized toads were used as lymphocyte donors. These results strongly suggest that in Xenopus, thymus-independent lymphocytes preferentially localize in the splenic white pulp, and thymus-derived lymphocytes possibly in the red pulp.
对未切除胸腺和早期切除胸腺的非洲爪蟾注射³H-胸腺嘧啶核苷，然后将来自胸腺、脾脏和外周血的标记淋巴细胞转移至组织相容性受体，通过放射自显影研究它们的分布。转移后，极高比例的标记胸腺细胞定位于未切除胸腺和切除胸腺受体的脾脏红髓中。标记的脾脏淋巴细胞在脾脏白髓中的定位密度明显高于红髓，尤其是在细胞转移后24小时。当使用早期切除胸腺的蟾蜍作为淋巴细胞供体时，标记淋巴细胞在白髓中的这种偏好更为明显。这些结果有力地表明，在非洲爪蟾中，非胸腺依赖性淋巴细胞优先定位于脾脏白髓，而胸腺衍生的淋巴细胞可能定位于红髓。
