[Changes in the functional activity of T- and B-lymphocytes in experimental infection due to different strains of the influenza virus].

In mice infected with influenza A2/Port Chalmers and B/Hong Kong viruses the formation of antibody-producing cells (APC) to the thymus-dependent antigen, sheep red blood cells (SRBC) was found to be inhibited much stronger than that to the thymus-independent antigen (polyvinylpyrrolidone K-90). Influenza A/PR-8/34 virus was approximately similarly active in both systems. Spleen cells of mouse donors infected with influenza virus were characterized by a markedly reduced capacity to form APC to ARBC when inoculated into irradiated recipients. This capacity was recovered if the donor spleen cells of infected animals were inoculated into recipients in mixture with T-lymphocytes of intact animals. Possible mechanisms of lymphocyte damage in influenza infection are discussed.