年龄对镉体外作用于大鼠肝脏细胞色素P-450浓度及单加氧酶活性的影响。
Influence of age on in vitro effect of cadmium on rat liver cytochrome P-450 concentration and monooxygenases activity.
作者信息
Jahn F, Klinger W
出版信息
Acta Pharmacol Toxicol (Copenh). 1982 Feb;50(2):85-8. doi: 10.1111/j.1600-0773.1982.tb00945.x.
Cadmium++ added in vitro destroys rat liver cytochrome P-450 (cyt. P-450) with increasing age by 25-50%. Ethylmorphine N-demethylation is inhibited only in rats 30-days old and thereafter. Ethoxycoumarin 0-deethylation is inhibited even in newborn rats, and the maximal inhibition appears to increase with age. It is concluded that in all age groups cadmium resistant cyt. P-450 subspecies are present. Ethoxycoumarin 0-deethylase activity possibly indicates the cadmium sensitive P-450 fraction.
体外添加的镉离子会随着大鼠年龄增长破坏其肝脏细胞色素P - 450（细胞色素P - 450），破坏程度达25% - 50%。仅在30日龄及以上的大鼠中，乙基吗啡N - 脱甲基作用受到抑制。即使在新生大鼠中，乙氧香豆素O - 脱乙基作用也受到抑制，且最大抑制作用似乎随年龄增长而增强。结论是，在所有年龄组中均存在对镉有抗性的细胞色素P - 450亚类。乙氧香豆素O - 脱乙基酶活性可能表明了对镉敏感的细胞色素P - 450部分。
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