Blaiss M S, Herrod H G, Crawford L V, Lieberman P L
Ann Allergy. 1982 Apr;48(4):210-4.
Inhaled beclomethasone dipropionate aerosol is a topically active corticosteroid that has proved to be of great value in treating asthma. The authors have examined the effect of inhaled beclomethasone dipropionate aerosol on circulating leukocytes and on immunological measurements in normal adult subjects. Subjects inhaled either 400 micrograms or 1600 micrograms as a single dose. White blood cell counts, total neutrophil counts, total eosinophil counts and total lymphocyte counts were determined at 0, 2, 4 and 6 hours following an 8:00 a.m. inhalation. Among the 11 subjects who inhaled 400 micrograms, the total white blood cell count increased significantly at six hours (p less than 0.05). The total neutrophil count was increased significantly at 2, 4 and 6 hours (p less than 0.05). Total eosinophil counts and total lymphocyte counts were diminished but not significantly. Among the five subjects inhaling 1600 micrograms similar findings were observed. Seventeen volunteers inhaled 200 micrograms of beclomethasone dipropionate qid for 24 hours. In addition to the above studies, T and B cell numbers were determined and lymphocyte transformation studies were performed. Although trends similar to those observed with single larger dose inhalations were seen, the changes were not statistically significant. The results of these studies indicate that inhaled beclomethasone dipropionate does have the potential to affect circulating leukocytes.
吸入用丙酸倍氯米松气雾剂是一种具有局部活性的皮质类固醇，已证明在治疗哮喘方面具有重要价值。作者研究了吸入用丙酸倍氯米松气雾剂对正常成年受试者循环白细胞和免疫指标的影响。受试者单次吸入400微克或1600微克。在上午8点吸入后0、2、4和6小时测定白细胞计数、总中性粒细胞计数、总嗜酸性粒细胞计数和总淋巴细胞计数。在吸入400微克的11名受试者中，白细胞总数在6小时时显著增加（p<0.05）。总中性粒细胞计数在2、4和6小时时显著增加（p<0.05）。总嗜酸性粒细胞计数和总淋巴细胞计数减少，但不显著。在吸入1600微克的5名受试者中观察到类似结果。17名志愿者每天4次吸入200微克丙酸倍氯米松，共24小时。除上述研究外，还测定了T细胞和B细胞数量，并进行了淋巴细胞转化研究。虽然观察到的趋势与单次较大剂量吸入时相似，但变化无统计学意义。这些研究结果表明，吸入用丙酸倍氯米松确实有可能影响循环白细胞。
