Poussier P, Nakhooda A F, Falk J A, Lee C, Marliss E B
Endocrinology. 1982 May;110(5):1825-7. doi: 10.1210/endo-110-5-1825.
The "BB" rat spontaneously develops insulitis followed by impaired glucose tolerance (IGT) and/or an insulin-dependent diabetic syndrome like that in man. All diabetic rats in this study showed marked lymphopenia in blood, lymph nodes, spleen, and thymus. Peripheral blood lymphopenia antedated glucoregulatory disturbances. All rats showing either insulitis with or without IGT or diabetes were lymphopenic. None with normal lymphocyte counts developed any abnormality. Diabetics showed marked decrease in the proportions of T+ lymphocytes in all tissues. The proportion of B (Ia+) lymphocytes was normal in blood, spleen and thymus, but increased in lymph nodes. However, in absolute terms both T and Ia+ lymphocytes were decreased. The subset decreased by the greatest proportion in all tissues was that which includes helper T lymphocytes. Thus: a) generalized lymphopenia most marked for T lymphocytes has been shown, b) helper T lymphocytes show proportionally the greatest reduction, c)thymic helper T deficit suggests a thymic origin of the lymphopenia, d) lymphopenia is a possible marker for susceptibility to the syndrome.
“BB”大鼠会自发发生胰岛炎，随后出现糖耐量受损（IGT）和/或类似人类的胰岛素依赖型糖尿病综合征。本研究中的所有糖尿病大鼠在血液、淋巴结、脾脏和胸腺中均表现出明显的淋巴细胞减少。外周血淋巴细胞减少早于糖调节紊乱。所有表现出胰岛炎伴或不伴IGT或糖尿病的大鼠均有淋巴细胞减少。淋巴细胞计数正常的大鼠均未出现任何异常。糖尿病大鼠所有组织中的T +淋巴细胞比例均显著降低。血液、脾脏和胸腺中B（Ia +）淋巴细胞的比例正常，但在淋巴结中增加。然而，从绝对值来看，T淋巴细胞和Ia +淋巴细胞均减少。在所有组织中比例下降最大的亚群是包括辅助性T淋巴细胞的亚群。因此：a）已显示以T淋巴细胞最为明显的全身性淋巴细胞减少，b）辅助性T淋巴细胞的比例下降最为显著，c）胸腺辅助性T细胞缺乏提示淋巴细胞减少起源于胸腺，d）淋巴细胞减少可能是该综合征易感性的一个标志。
