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T淋巴细胞中的GIMAP蛋白

GIMAP Proteins in T-Lymphocytes.

作者信息

Filén Sanna, Lahesmaa Riitta

机构信息

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Tykistökatu 6 B, P.O. BOX 123, 20520 Turku, Finland.

出版信息

J Signal Transduct. 2010;2010:268589. doi: 10.1155/2010/268589. Epub 2010 Aug 31.

DOI:10.1155/2010/268589
PMID:21637352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3100574/
Abstract

(GIMAPs) GTPase of the immunity associated protein family are a novel protein family of putative small GTPases. GIMAPs are mainly expressed in the cells of the immune system and have been associated with immunological functions, such as thymocyte development, apoptosis of peripheral lymphocytes and T helper cell differentiation. GIMAPs have also been linked to immunological diseases, such as T cell lymphopenia, leukemia and autoimmune diseases. In this review we examine the role of GIMAP proteins in T-lymphocyte biology.

摘要

免疫相关蛋白家族的GTP酶（GIMAPs）是一类假定的小GTP酶的新型蛋白家族。GIMAPs主要在免疫系统细胞中表达，并与免疫功能相关，如胸腺细胞发育、外周淋巴细胞凋亡和辅助性T细胞分化。GIMAPs还与免疫性疾病有关，如T细胞淋巴细胞减少症、白血病和自身免疫性疾病。在本综述中，我们研究了GIMAP蛋白在T淋巴细胞生物学中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6690/3100574/02bfbf2cd961/JST2010-268589.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6690/3100574/cd5c2554c93f/JST2010-268589.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6690/3100574/e60baa4173ba/JST2010-268589.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6690/3100574/03eab7df10bd/JST2010-268589.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6690/3100574/02bfbf2cd961/JST2010-268589.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6690/3100574/cd5c2554c93f/JST2010-268589.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6690/3100574/e60baa4173ba/JST2010-268589.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6690/3100574/03eab7df10bd/JST2010-268589.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6690/3100574/02bfbf2cd961/JST2010-268589.004.jpg

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