Ryabchenko N I, Ivannik B P
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Apr;41(4):389-99. doi: 10.1080/09553008214550431.
The yields of immediate DNA single-strand breaks in normal tumour tissues of irradiated animals were measured by a viscosimetric method of determination of high-polymer single-strand DNA molecular weight in alkaline nuclear lysates. It has been shown that in irradiated thymus, bone marrow leukocytes, Ehrlich ascitic carcinoma and Zaidel hepatoma cells (first group by tissues) in vivo the yields of DNA single-strand breaks were characterized by 80 to 130 eV per break. In in vivo irradiated liver, lymph node, spleen, and sarcoma 180 cells (second group of tissues) the yields of DNA single-strand breaks have been characterized by 30 to 40 eV per break. DNA single-strand breaks of the first group of tissues have rejoined 1 hour after the irradiation in vivo; DNA single-strand breaks of the second group have not done so.
通过在碱性核裂解物中测定高分子单链DNA分子量的粘度测定法，测量了受辐照动物正常肿瘤组织中即时DNA单链断裂的产量。结果表明，在体内受辐照的胸腺、骨髓白细胞、艾氏腹水癌和扎伊德尔肝癌细胞（第一组组织）中，DNA单链断裂的产量特征为每断裂80至130电子伏特。在体内受辐照的肝脏、淋巴结、脾脏和肉瘤180细胞（第二组组织）中，DNA单链断裂的产量特征为每断裂30至40电子伏特。第一组组织的DNA单链断裂在体内辐照1小时后重新连接；第二组的DNA单链断裂则没有。
