大鼠体内氧化铀-233和硝酸铀酰-233的行为。

The behaviour of uranium-233 oxide and uranyl-233 nitrate in rats.

作者信息

Cooper J R, Stradling G N, Smith H, Ham S E

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Apr;41(4):421-33. doi: 10.1080/09553008214550461.

Abstract

233UO2 and 233UO2(NO3)2 in aqueous suspension have been administered to rats by pulmonary intubation. The 233U associated with the fraction of the 233UO2 less than 4 nm in diameter translocates from lungs to blood at the same rapid rate as 233U from 233UO2(NO3)2. Identical reactions with blood plasma and lung fluid were observed whether the 233U was administered as less than 4 nm 233UO2 particles or 233UO2(NO3)2. It is suggested that oxidation of UO2 to UO3 occurs followed by the formation of uranyl ion. In blood plasma, approximately 50 per cent of the 233U is bound to transferrin, 25 per cent to citrate and 25 per cent on bicarbonate.

摘要

已通过肺插管将水悬浮液中的233UO₂和233UO₂(NO₃)₂给予大鼠。与直径小于4纳米的233UO₂部分相关的233U从肺转移到血液的速度与来自233UO₂(NO₃)₂的233U一样快。无论233U是以小于4纳米的233UO₂颗粒还是233UO₂(NO₃)₂的形式给药，在血浆和肺液中都观察到相同的反应。有人提出，UO₂先氧化为UO₃，然后形成铀酰离子。在血浆中，约50%的233U与转铁蛋白结合，25%与柠檬酸盐结合，25%与碳酸氢盐结合。