Mella O, Dahl O, Bang G, Engedal H, Gøthlin J, Lunde O D
Cancer. 1982 Jul 15;50(2):207-11. doi: 10.1002/1097-0142(19820715)50:2<207::aid-cncr2820500206>3.0.co;2-n.
A 13-year-old girl was treated surgically for a giant-cell tumor of bone originating in the talus and for a recurrence in the distal tibia. She later developed liver and lung metastases and was treated for two years, five months with a combination of vincristine, doxorubicin, cyclophosphamide and actinomycin-D, and thereafter with high-dose methotrexate/vincristine with citrovorum factor rescue. A good response was obtained and the patient is without evidence of disease 12 months after a salvage thoracotomy for residual disease in the left lung. Aspects of this singular case are discussed.
一名13岁女孩接受了手术治疗，以切除起源于距骨的骨巨细胞瘤及胫骨远端的复发病灶。她后来出现了肝肺转移，并接受了两年零五个月的联合化疗，使用药物包括长春新碱、阿霉素、环磷酰胺和放线菌素-D，之后采用大剂量甲氨蝶呤/长春新碱并辅以亚叶酸钙解救治疗。治疗取得了良好效果，在因左肺残留病灶行挽救性开胸手术后12个月，患者无疾病迹象。本文讨论了这一特殊病例的相关情况。
