Barrie K P, Gelatt K N, Gum G G, Samuelson D A
Am J Vet Res. 1982 Feb;43(2):207-16.
Injection of 150, 500, or 750 U of alpha chymotrypsin into the posterior chamber of clinically normal Beagles resulted in changes in intraocular pressure and iridocyclitis. In the 6 eyes treated with 500 or 750 U, lens subluxation occurred in 4 eyes, retinal detachment in 1 eye, retinal degeneration in 1 eye, and optic nerve degeneration in 6 eyes. Scanning electron microscopic changes included dose-related zonulolysis and zonulary remnants within the aqueous humor outflow pathways. Ultrastructural changes by transmission microscopy of the optic nerve degeneration revealed loss of axoplasm and organelles and disruption of the myelin sheaths. Retinal and optic nerve changes may represent the direct toxic effects of alpha chymotrypsin and/or the indirect effects of increased intraocular pressure.
向临床正常的比格犬后房注射150、500或750单位的α-糜蛋白酶会导致眼压变化和虹膜睫状体炎。在接受500或750单位治疗的6只眼中，4只眼发生晶状体半脱位，1只眼发生视网膜脱离，1只眼发生视网膜变性，6只眼发生视神经变性。扫描电子显微镜检查的变化包括与剂量相关的悬韧带溶解以及房水流出途径内的悬韧带残余物。视神经变性的透射显微镜超微结构变化显示轴浆和细胞器丢失以及髓鞘破坏。视网膜和视神经变化可能代表α-糜蛋白酶的直接毒性作用和/或眼压升高的间接作用。
