Saroglou G, Paniara-Volika O, Sima A, Paraskevopoulou E, Makris G, Hatzimichelakis N, Vassilopoulos N, Kontomichalou P
Clin Ther. 1982;4(6):442-9.
Twenty-four patients with pulmonary infections (7 pneumoniae, 17 exacerbations of chronic bronchitis) were treated with a combination of 250 mg of amoxicillin and 125 mg of clavulanic acid supplemented by 500 mg of amoxicillin every eight hours. All patients showed good clinical, roentgenological, and bacteriological response. Bacteria were cleared from sputum by the third day of treatment in half of the patients and by the end of treatment in all but one of the others. Pathogens eradicated from sputum, with concurrent clinical cure, included gram-negative bacteria producing cephalosporinases shown to be resistant to the combination drug by both disk and minimal inhibitory concentration determinations.
24例肺部感染患者（7例肺炎，17例慢性支气管炎急性加重）接受了250毫克阿莫西林与125毫克克拉维酸联合治疗，每8小时补充500毫克阿莫西林。所有患者在临床、影像学和细菌学方面均显示出良好反应。一半患者在治疗第3天时痰液中的细菌被清除，其余患者除1例之外在治疗结束时细菌均被清除。痰液中根除的病原体，同时伴有临床治愈，包括通过纸片扩散法和最低抑菌浓度测定显示对联合用药耐药的产头孢菌素酶革兰氏阴性菌。
