Pertzelan A, Yalon L, Kauli R, Laron Z
Clin Endocrinol (Oxf). 1982 Apr;16(4):359-68. doi: 10.1111/j.1365-2265.1982.tb00728.x.
During treatment of girls with oestrogen deficiency we observed different patterns of breast development in response to therapy. The forty-five girls studied fell into four groups: Group A, gonadal dysgenesis; Group B, isolated gonadotrophin deficiency; Group C, multiple pituitary hormone deficiencies; Group D, congenital adrenal hyperplasia (17-alpha-hydroxylase deficiency). Treatment with oestrogen was given in an identical manner to all. In the patients with gonadal dysgenesis, in whom the hypothalamic-pituitary function was normal, treatment led to full breast development. In isolated gonadotrophin deficiency and multiple pituitary hormone deficiency breast development was incomplete even after 3 years or more of oestrogen treatment. The conspicuous difference in the hormonal status is that the latter two groups lack gonadotrophins, while in gonadal dysgenesis these hormones are grossly elevated. Our conclusion is that gonadotrophins play an important role in mammary gland development, a finding not previously described. In the girl with 17-alpha-hydroxylase deficiency we observed that cortisol was necessary, in addition to sex hormones, for normal breast development.
在对雌激素缺乏的女孩进行治疗期间，我们观察到了不同的乳房发育模式对治疗的反应。所研究的45名女孩分为四组：A组，性腺发育不全；B组，孤立性促性腺激素缺乏；C组，多种垂体激素缺乏；D组，先天性肾上腺增生（17-α-羟化酶缺乏）。对所有女孩均以相同方式给予雌激素治疗。在性腺发育不全且下丘脑-垂体功能正常的患者中，治疗导致乳房完全发育。在孤立性促性腺激素缺乏和多种垂体激素缺乏的患者中，即使经过3年或更长时间的雌激素治疗，乳房发育仍不完全。激素状态的显著差异在于后两组缺乏促性腺激素，而在性腺发育不全中这些激素显著升高。我们的结论是促性腺激素在乳腺发育中起重要作用，这一发现此前未曾有过描述。在患有17-α-羟化酶缺乏的女孩中，我们观察到除性激素外，皮质醇对于正常乳房发育也是必需的。
