El-Labban N G
Histopathology. 1982 May;6(3):317-25. doi: 10.1111/j.1365-2559.1982.tb02726.x.
Langerhans cells and macrophages have been studied in both oral lichen planus lesions and histiocytosis X. Many of the macrophages in both lesions contained phagolysosomes in various stages of degradation. Some of these phagolysosomes were found to develop slender processes and very narrow extensions containing little processed phagocytosed material. These latter structures were indistinguishable from Langerhans granules and were termed Langerhans granule-like structures. There is enough evidence in the present study to suggest that typical Langerhans granules evolve from Langerhans granule-like structures and to confirm that Langerhans cells are a type of macrophage which at one stage of their development show Langerhans granules.
在口腔扁平苔藓病变和组织细胞增多症X中均对朗格汉斯细胞和巨噬细胞进行了研究。在这两种病变中，许多巨噬细胞含有处于不同降解阶段的吞噬溶酶体。发现其中一些吞噬溶酶体形成细长的突起和非常狭窄的延伸部分，所含已处理的吞噬物质很少。这些后者的结构与朗格汉斯颗粒无法区分，被称为朗格汉斯颗粒样结构。本研究中有足够的证据表明典型的朗格汉斯颗粒由朗格汉斯颗粒样结构演变而来，并证实朗格汉斯细胞是巨噬细胞的一种类型，在其发育的一个阶段表现出朗格汉斯颗粒。
