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碘曲仑人体研究——黄疸和无黄疸患者的血浆蛋白结合、肾脏及胆汁排泄研究

Iotroxamide studies in man--plasma binding, renal and biliary excretion studies in jaundiced and anicteric patients.

作者信息

Doran J, Vennart W, Richmond C R, Bell G D

出版信息

Br J Clin Pharmacol. 1978 Oct;6(4):311-7. doi: 10.1111/j.1365-2125.1978.tb00857.x.

Abstract

1.A decrease in the plasma binding of iotroxamide was found in jaundiced people. 2. The decrease in binding was associated with an enhancement in renal excretion. 3. Iotroxamide consistently gave higher biliary iodine concentrations than ioglycamide.

摘要
  1. 在黄疸患者中发现碘曲仑的血浆结合率降低。2. 结合率降低与肾排泄增加有关。3. 碘曲仑的胆汁碘浓度始终高于碘甘卡明。

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本文引用的文献

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Binding of roentgenographic contrast media to serum albumin.
Invest Radiol. 1967 Nov-Dec;2(6):396-400. doi: 10.1097/00004424-196711000-00017.
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Adverse reactions to contrast agents. Scope of problem.造影剂的不良反应。问题范围。
Invest Radiol. 1970 Nov-Dec;5(6):374-91. doi: 10.1097/00004424-197011000-00002.
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A new approach to the determination of protein-bound bilirubin displacement and its applications.
Ann N Y Acad Sci. 1973 Nov 26;226:238-46. doi: 10.1111/j.1749-6632.1973.tb20485.x.
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Determination of plasma levels of biliary contrast media.胆汁造影剂血浆水平的测定。
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