肯尼亚曼氏血吸虫感染患者的非特异性细胞介导免疫
Non-specific cell mediated immunity in patients infected with Schistosoma mansoni in Kenya.
作者信息
Cottrell B J, Humber D, Sturrock R F, Seitz H, Rees P
出版信息
Trans R Soc Trop Med Hyg. 1982;76(2):234-7. doi: 10.1016/0035-9203(82)90285-1.
Parameters of in vitro cell-mediated immunity (CMI) have been measured in the local Kenyan population infected with Schistosoma mansoni. Lymphocyte responses to the non-specific T cell mitogens Concanavalin A (Con A) and Phytohaemagglutinin (PHA) were reduced in about 60% of schistosomiasis patients. Lymphocytes from control uninfected, and S. mansoni-infected donors formed equal numbers of spontaneous rosettes with sheep red blood cells, indicating that there was no over-all reduction in the percentage numbers of T cells in the schistosomiasis patients.
已对肯尼亚当地感染曼氏血吸虫的人群进行了体外细胞介导免疫（CMI）参数的测定。约60%的血吸虫病患者对非特异性T细胞有丝分裂原刀豆球蛋白A（Con A）和植物血凝素（PHA）的淋巴细胞反应降低。来自未感染对照者和感染曼氏血吸虫供体的淋巴细胞与绵羊红细胞形成的自发玫瑰花结数量相同，这表明血吸虫病患者的T细胞百分比总体上没有降低。
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