非细菌性血栓性心内膜炎（NBTE）瓣膜赘生物的免疫组织学研究。

Immunohistological studies on valvular vegetations in nonbacterial thrombotic endocarditis (NBTE).

作者信息

Lehto V P, Stenman S, Somer T

出版信息

Acta Pathol Microbiol Immunol Scand A. 1982 May;90(3):207-11. doi: 10.1111/j.1699-0463.1982.tb00083_90a.x.

DOI:10.1111/j.1699-0463.1982.tb00083_90a.x

Abstract

Thrombi and thrombus formation in nonbacterial thrombotic endocarditis (NBTE) were studied using light microscopy and immunohistology. Samples from vegetations on cardiac valves were taken at autopsy from five patients with NBTE and adenocarcinoma as an underlying disease. Morphological studies disclosed proliferative changes underneath the thrombi. In immunofluorescence microscopy, focal deposits of immunoglobulins and complement components Clq and C3 were found. The results suggest that immune complexes, elicited by the underlying malignant process, may play important role in the pathogenesis of the thrombus formation in NBTE.

摘要

运用光学显微镜和免疫组织学方法对非细菌性血栓性心内膜炎（NBTE）中的血栓及血栓形成进行了研究。从五例患有NBTE且潜在疾病为腺癌的患者尸检中获取心脏瓣膜赘生物样本。形态学研究揭示了血栓下方的增殖性变化。在免疫荧光显微镜下，发现了免疫球蛋白以及补体成分Clq和C3的局灶性沉积。结果表明，由潜在恶性病变引发的免疫复合物可能在NBTE血栓形成的发病机制中起重要作用。