Kerkvliet N I, Baecher-Steppan L
Immunopharmacology. 1982 Jun;4(3):213-24. doi: 10.1016/0162-3109(82)90003-0.
Chronic exposure of C57BL/6 mice to lead acetate in the drinking water enhanced the growth of primary Moloney sarcoma virus (MSV)-induced tumors. Regression of MSV-induced tumors was not prevented by lead exposure and lead-treated animals were more resistant to late sarcoma development following primary tumor regression. The primary cell-mediated cytotoxic response in the spleen or lymph nodes of MSV-tumor bearing mice was significantly augmented by lead exposure. This augmentation appeared to reflect the increased antigenic stimulation resulting from the enhanced primary tumor growth in lead-exposed animals. Using an allogeneic tumor model, under conditions of similar antigenic stimulation, little effect of lead on T cell-mediated cytotoxicity was observed. On the other hand, macrophage phagocytic activity was significantly depressed in lead-exposed mice. Coupled with a decrease in the total number of macrophages recovered from lead-exposed mice, the results suggested significant impairment of macrophages function by lead. The influence of lead-induced macrophage dysfunction on tumor growth is discussed.
将C57BL/6小鼠长期暴露于饮用水中的醋酸铅中，可促进原发性莫洛尼肉瘤病毒（MSV）诱导肿瘤的生长。铅暴露并不能阻止MSV诱导肿瘤的消退，并且铅处理的动物在原发性肿瘤消退后对晚期肉瘤的发展更具抵抗力。铅暴露显著增强了携带MSV肿瘤小鼠脾脏或淋巴结中的原发性细胞介导的细胞毒性反应。这种增强似乎反映了铅暴露动物中原发性肿瘤生长增强导致的抗原刺激增加。在同种异体肿瘤模型中，在相似的抗原刺激条件下，未观察到铅对T细胞介导的细胞毒性有显著影响。另一方面，铅暴露小鼠的巨噬细胞吞噬活性显著降低。再加上从铅暴露小鼠中回收的巨噬细胞总数减少，结果表明铅对巨噬细胞功能有显著损害。本文讨论了铅诱导的巨噬细胞功能障碍对肿瘤生长的影响。
