Isaacs N S, Sunman G, Reading C
J Antibiot (Tokyo). 1982 May;35(5):589-93. doi: 10.7164/antibiotics.35.589.
The inhibition characteristics of 25 monocyclic beta-lactams mainly with an amido function at C3 have been studied against the beta-lactamases produced by 4 bacterial types. Significant levels of inhibition were found for only a few of the compounds tested and primarily against Staphylococcus beta-lactamase. The most active inhibitor tested, 3-p-nitrophenylacetamido-4-phenylazetidin-2-one, was found to require a cis geometry, the trans isomer being almost inactive.
对主要在C3位带有酰胺官能团的25种单环β-内酰胺类化合物针对4种细菌产生的β-内酰胺酶的抑制特性进行了研究。在所测试的化合物中，仅发现少数几种具有显著水平的抑制作用，且主要针对葡萄球菌β-内酰胺酶。所测试的最具活性的抑制剂3-对硝基苯乙酰氨基-4-苯基氮杂环丁烷-2-酮被发现需要顺式构型，反式异构体几乎没有活性。
