Casey M L, MacDonald P C
J Clin Endocrinol Metab. 1982 Oct;55(4):804-6. doi: 10.1210/jcem-55-4-804.
In the present investigation, we demonstrated the presence of steroid 21-hydroxylase activity in microsome-enriched fractions prepared from homogenates of aortal tissues of human abortuses and a prepubertal boy. The specific activities of this enzyme in microsomes prepared from aortal tissue of various abortuses varied but was similar to that found previously in microsomes prepared from human fetal kidney tissue. However, the specific activity of steroid 21-hydroxylase in microsomes prepared from smooth muscle tissue of the aorta of a prepubertal boy was extraordinarily high, viz., 705 pmol x h-1 x mg-1 protein. Thus the potential exists for the formation of deoxycorticosterone (DOC) in aorta, another tissue site of DOC action.
在本研究中，我们证明了在从人工流产胎儿和青春期前男孩的主动脉组织匀浆制备的富含微粒体的组分中存在类固醇21-羟化酶活性。从不同人工流产胎儿的主动脉组织制备的微粒体中该酶的比活性有所不同，但与先前在从人胎儿肾脏组织制备的微粒体中发现的相似。然而，从青春期前男孩主动脉平滑肌组织制备的微粒体中类固醇21-羟化酶的比活性非常高，即705 pmol×h-1×mg-1蛋白质。因此，在主动脉中存在形成脱氧皮质酮（DOC）的可能性，DOC作用的另一个组织部位。
