Hölzle E, Kligman A M
Br J Dermatol. 1978 Aug;99(2):117-37. doi: 10.1111/j.1365-2133.1978.tb01973.x.
Anhidrosis was induced in volunteers by covering the skin with an impermeable plastic film. The degree of sweat suppression and miliaria after a thermal stimulus was directly proportional to the increase in the density of resident aerobic bacteria, notably cocci. No anhidrosis resulted when antibacterial substances were used to prevent the expansion of the microflora. Histological study showed a PAS-positive diastase resistant amorphous mass deep within the acrosyringium after 2 days of occlusion, accompanied by a periductal dermal infiltration of leukocytes. After another 2 days the duct became clogged by an amalgam of degenerating leukocytes. This impaction sloughed after about 3 weeks as a result of epidermal renewal. Colonies of bacteria were never found within the ducts. It is postulated that cocci secrete a toxin which injures luminal cells and precipitates a cast within the lumen. Infiltration by leukocytes creates an impaction which completely obstructs the passage of sweat for several weeks.
通过用不透水的塑料薄膜覆盖皮肤，在志愿者身上诱发无汗症。热刺激后汗液分泌抑制程度和粟丘疹与需氧常驻菌尤其是球菌密度的增加成正比。当使用抗菌物质防止微生物群扩张时，不会导致无汗症。组织学研究显示，闭塞2天后，顶泌汗腺导管深部有PAS阳性、淀粉酶抵抗的无定形物质，伴有导管周围真皮白细胞浸润。再过2天后，导管被退变白细胞的混合物堵塞。由于表皮更新，这种堵塞物在约3周后脱落。在导管内从未发现细菌菌落。据推测，球菌分泌一种毒素，损伤管腔细胞并在管腔内形成铸型。白细胞浸润造成堵塞，完全阻碍汗液排出数周。
