Quencer R M
AJR Am J Roentgenol. 1982 Sep;139(3):561-8. doi: 10.2214/ajr.139.3.561.
Five infant baboons were examined with computed tomography (CT) during the first year of their lives to determine the rate and degree of normal white matter maturation in frontal, occipital, and parietal areas. The increase in CT numbers with age was correlated with gross and histologic specimens. Two phases of maturation were identified: a rapid phase (first 8-12 weeks) and a gradual phase (after 12 weeks). Frontal white matter was the most immature in the immediate postnatal period but it became equal in attenuation to the other regions by 4 weeks of age. Knowledge of white matter maturation rates may be particularly useful in cases of neonatal hypoxia/ischemia where zones of periventricular hypodensity are identified. The failure of such regions to follow a normal rate of maturation may indicate damage to the white matter and have significant prognostic implications.
五只幼年狒狒在出生后的第一年接受了计算机断层扫描（CT）检查，以确定额叶、枕叶和顶叶区域正常白质成熟的速率和程度。CT数值随年龄的增加与大体标本和组织学标本相关。确定了两个成熟阶段：快速阶段（最初8 - 12周）和渐进阶段（12周后）。额叶白质在出生后即刻最为不成熟，但在4周龄时其衰减程度与其他区域相等。白质成熟速率的知识在新生儿缺氧/缺血且识别出脑室周围低密度区的病例中可能特别有用。这些区域未能遵循正常的成熟速率可能表明白质受损，并具有重要的预后意义。
