Baierl P, Förster C, Fendel H, Naegele M, Fink U, Kenn W
Department of Radiology, University of Munich, FRG.
Pediatr Radiol. 1988;18(3):183-9. doi: 10.1007/BF02390391.
Fifty children between 3 months postnatal and 16 years of age were examined by means of a 1.5 T superconductive magnet, run at 0.35 and 1.0 T. The myelination was studied qualitatively and quantitatively (relaxation times, proton densities, image contrast). With increasing age, a decrease of T1 and proton density of white matter was found, which was complete at one year of age. In regions with a slow progression of myelination, gray/white matter contrast showed an increase up to the end of the first decade. Pathological white matter maturation was diagnosed either as an abnormal transformation of myelin (characterized by abnormal relaxation values), or as a deficient or delayed myelin formation (in comparison with age-matched controls).
对50名出生后3个月至16岁的儿童使用1.5T超导磁体进行检查，磁体分别在0.35T和1.0T下运行。对髓鞘形成进行了定性和定量研究（弛豫时间、质子密度、图像对比度）。随着年龄的增长，发现白质的T1和质子密度降低，在1岁时完成。在髓鞘形成进展缓慢的区域，灰质/白质对比度在第一个十年末之前呈增加趋势。病理性白质成熟被诊断为髓鞘的异常转变（以异常弛豫值为特征），或髓鞘形成不足或延迟（与年龄匹配的对照组相比）。
