Hiramatsu M, Hatakeyama K, Kumegawa M, Minami N
Arch Oral Biol. 1982;27(6):517-8. doi: 10.1016/0003-9969(82)90094-2.
The 7S nerve-growth factor (7S NGF), high molecular weight epidermal growth factor (HMW-EGF) and their subunits were isolated from mouse submandibular gland. Plasminogen activator activity was found in the 7S NGF and HMW-EGF, as well as in the gamma subunit and EGF-binding protein. Later activities were two- or three-fold higher than those of original growth factors. The alpha subunit, beta subunit and low molecular weight EGF showed no activity. The gamma 1, gamma 2 and gamma 3 subunits of 7S NGF showed plasminogen activator activity almost equal to that of the original gamma subunit.
