新生儿α1-抗胰蛋白酶（PI）亚型的分布。

Distribution of alpha 1-antitrypsin (PI) subtypes from newborns.

作者信息

Mulley J C

出版信息

Aust J Exp Biol Med Sci. 1982 Apr;60(Pt 2):207-9. doi: 10.1038/icb.1982.23.

DOI:10.1038/icb.1982.23

Abstract

PI phenotypes were determined from 420 cord bloods from Adelaide. Allele frequencies for the subvariants PIMI, PIM2 and PI*M3 were 0.73, 0.14 and 0.09, respectively. The combined frequency of other alleles was 0.04. This relatively high level of variation makes PI useful for gene mapping, paternity testing and zygosity testing. For this locus the average probability of detecting non-paternity in this population is 28%.

摘要

从阿德莱德的420份脐带血中确定了PI表型。PIMI、PIM2和PI*M3亚变体的等位基因频率分别为0.73、0.14和0.09。其他等位基因的合并频率为0.04。这种相对较高的变异水平使得PI在基因定位、亲子鉴定和血型鉴定中很有用。对于这个基因座，在该人群中检测到非父系关系的平均概率为28%。