Pang D C, Sperelakis N
Eur J Pharmacol. 1982 Jul 16;81(3):403-9. doi: 10.1016/0014-2999(82)90105-4.
The action of four calcium antagonistic drugs, including verapamil, bepridil, nifedipine, and diltiazem, on calcium binding to cardiac sarcolemma from guniea pig was tested. It was found that verapamil (10(-6) to 10(-5) M) inhibited calcium binding to a great extent. Bepridil at the same concentrations was less potent than verapamil in the depression of calcium binding. Nifedipine and diltiazem did not affect sarcolemmal calcium binding. The differential action of the calcium antagonistic drugs was discussed.
测试了四种钙拮抗药，包括维拉帕米、苄普地尔、硝苯地平和地尔硫䓬，对豚鼠心肌肌膜钙结合的作用。发现维拉帕米（10⁻⁶至10⁻⁵M）在很大程度上抑制钙结合。相同浓度下，苄普地尔在抑制钙结合方面的效力低于维拉帕米。硝苯地平和地尔硫䓬不影响肌膜钙结合。并对钙拮抗药的不同作用进行了讨论。
