Marusić M, Kindred B
Immunol Commun. 1982;11(2):83-96. doi: 10.3109/08820138209057744.
The ability of normal, parental type T cells to initiate an immune response and to generate memory T cells in T-cell deficient F1 mice was investigated using two types of F1 recipients: Congenitally athymic (nude) mice and thymectomized, lethally irradiated, syngeneic bone marrow reconstituted (TIR) mice. In contrast to normal syngeneic T cells, normal parental type T cells elicited neither immune response nor memory T cells in F1 T-cell deficient mice. Parental T cells were ineffective even when obtained from chimeric donors tolerant to the second parental type transplantation antigens and normal, parental T cells did not counteract the restorative activity of F1 T cells in F1 T-cell-deficient recipients. These two latter findings exclude a suppression due to an ongoing GVH reaction as a possible cause for failure of parental T cells to restore F1 T-cell-deficient mice.
利用两种类型的F1受体，研究了正常亲代型T细胞在T细胞缺陷的F1小鼠中启动免疫反应并产生记忆T细胞的能力：先天性无胸腺（裸）小鼠和胸腺切除、致死性照射、同基因骨髓重建（TIR）小鼠。与正常同基因T细胞相比，正常亲代型T细胞在F1 T细胞缺陷小鼠中既不引发免疫反应也不产生记忆T细胞。即使亲代T细胞来自对第二种亲代型移植抗原耐受的嵌合供体，它们也无效，并且正常亲代T细胞不会抵消F1 T细胞在F1 T细胞缺陷受体中的恢复活性。后两个发现排除了由于持续的移植物抗宿主反应导致的抑制作用，这是亲代T细胞无法恢复F1 T细胞缺陷小鼠的可能原因。
