Pike V W, Eakins M N, Allan R M, Selwyn A P
Int J Appl Radiat Isot. 1982 Jul;33(7):505-12. doi: 10.1016/0020-708x(82)90003-5.
A method of obtaining an injectable solution of acetate labelled in the carboxyl group with the short-lived positron-emitting radionuclide, 11C (t12 = 20.4 min), is described. In the method labelling is achieved via the carbonation of freshly prepared methylmagnesium bromide with 11C-labelled carbon dioxide produced by the 14N(p, alpha)11C nuclear reaction. The method is fast (20 min) and produces sterile, apyrogenic [1-11C]acetate in high radiochemical yield (72 +/- 12%) and in high specific activity (greater than 18.5 GBq/mumol: greater than 0.5 Ci/mumol). The radiochemical purity of the radiopharmaceutical was found to exceed 95% by thin layer and high pressure liquid chromatography. Evidence presented shows that [1-11C]acetate has considerable value as an agent for investigating myocardial metabolism by positron emission tomography.
描述了一种获得用短寿命正电子发射放射性核素(^{11}C)（半衰期(t_{1/2}=20.4)分钟）在羧基处标记的醋酸盐注射溶液的方法。在该方法中，标记是通过将新制备的甲基溴化镁与由(^{14}N(p,\alpha)^{11}C)核反应产生的(^{11}C)标记的二氧化碳进行碳化来实现的。该方法快速（20分钟），并以高放射化学产率（(72\pm12%)）和高比活度（大于(18.5GBq/μmol)：大于(0.5Ci/μmol)）产生无菌、无热原的([1-^{11}C])醋酸盐。通过薄层色谱法和高压液相色谱法发现该放射性药物的放射化学纯度超过(95%)。所提供的证据表明，([1-^{11}C])醋酸盐作为一种通过正电子发射断层扫描研究心肌代谢的试剂具有相当大的价值。
