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[肠道血管发育异常或血管扩张。8例个人病例报告]

[Angiodysplasias or vascular ectasias of the intestine. Report on 8 personal cases].

作者信息

Mouiel J, Delmont J, Rampal P, Bertrand J C, Mazarguil P, Loubiere M

出版信息

J Chir (Paris). 1982 Jun-Jul;119(6-7):419-28.

PMID:6981652
Abstract

Angiodysplasia or vascular ectasia of the intestine is a new pathological entity which was initially revealed by arteriography. More recently it has been found by coloscopy and is considered to be responsible for many cases of intestinal bleeding, especially in older patients The present study is based on eight patients including 2 cases of microscopic bleeding, 4 of massive hemorrhage, and 2 asymptomatic cases. There is a clear difference between intestinal angiodysplasia and other forms of vascular malformations, even though its pathogenesis is still in question. Whereas in older patients it is acquired, typically in the caecum. It can also exist congenitally in younger patients and in other locations. However, identical lesions may be observed at all levels of the digestive tract in association with certain diseases, most often vascular atheroma, but also diverse intestinal diseases (diverticulitis, colitis, polyps, cancer) and even iatrogenic diseases. Even though these malformations are frequent, the lesions often go unrecognized because special histological technics are required to reveal the arteriovenous fistulas. The major circumstance leading to this diagnosis is anemia due either to occult intestinal bleeding or massive hemorrhage (after exclusion of prevalent associated disease such as diverticulosis). Occasionally latent angiodysplasia is revealed during studies undertaken for associated disease. Positive diagnosis is based on selective angiography during massive bleeding and on endoscopic examination in case of anemia from occult bleeding. Surgical treatment should be undertaken in case of major blood loss. This usually consists of resection of the ascending colon, the most frequent site of the lesion. It is recommended that an even longer colonic segment be resected in case of associated diverticulosis. The preferred treatment of limited forms with few symptoms depends on more recent technics such as endoscopic electrocoagulation. In conclusion, many cases if occult intestinal bleeding can be explained by angiodysplasia which thus deserves better understanding and recognition.

摘要

肠道血管发育异常或血管扩张是一种新的病理实体,最初由动脉造影发现。最近通过结肠镜检查也发现了这种情况,它被认为是许多肠道出血病例的病因,尤其是在老年患者中。本研究基于8例患者,其中包括2例微量出血、4例大量出血和2例无症状病例。肠道血管发育异常与其他形式的血管畸形之间存在明显差异,尽管其发病机制仍存在疑问。在老年患者中,它是后天获得的,典型部位是盲肠。它也可能先天性存在于年轻患者或其他部位。然而,在消化道的各个层面都可能观察到相同的病变,与某些疾病相关,最常见的是血管动脉粥样硬化,但也包括各种肠道疾病(憩室炎、结肠炎、息肉、癌症)甚至医源性疾病。尽管这些畸形很常见,但病变往往未被识别,因为需要特殊的组织学技术来揭示动静脉瘘。导致这种诊断的主要情况是由于隐匿性肠道出血或大量出血引起的贫血(排除诸如憩室病等常见相关疾病后)。偶尔,在对相关疾病进行检查时会发现潜在的血管发育异常。阳性诊断基于大量出血时的选择性血管造影以及隐匿性出血导致贫血时的内镜检查。如果出现大量失血,应进行手术治疗。这通常包括切除升结肠,这是病变最常见的部位。如果伴有憩室病,建议切除更长的结肠段。对于症状较少的局限性病变,首选治疗方法取决于诸如内镜电凝等最新技术。总之,许多隐匿性肠道出血病例可以用血管发育异常来解释,因此值得更好地理解和认识。

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