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两栖类细有髓神经纤维中的钾离子通透性。

Potassium permeability in thin amphibian myelinated fibres.

作者信息

Brismar T

出版信息

Pflugers Arch. 1982 Jun;393(4):348-50. doi: 10.1007/BF00581423.

DOI:10.1007/BF00581423
PMID:6981796
Abstract

Potential clamp analysis of thin (10-12 micrometers) myelinated fibres from amphibia (Xenopus laevis and Rana temporaria) showed that they had a large delayed K-permeability (PK) and a PK/PNa-ratio of 0.32, which is similar to the ratio in large (25-30 micrometers) frog fibres. These results agree with earlier evidence of a large delayed PK in 10-15 micrometers Rana fibres; a recent description of a size-dependent difference in PK was thus not confirmed. The large PK (0.32 cm3s-1 X 10(-9) in 10-12 micrometers amphibian fibres contrasted with the small PK (0.05 cm3 s-1 X 10(-9) in 12 micrometers rat fibres. Frog and toad fibres also had a larger nodal capacitance (4 pF), but smaller leak conductance (18 nS) than rat fibres (1.4 pF and 29 nS). These differences may be related to the morphological evidence of a more open node with a larger surface area in the amphibian as compared to the rat node.

摘要

对来自两栖动物(非洲爪蟾和欧洲林蛙)的细(10 - 12微米)有髓纤维进行的电压钳分析表明,它们具有较大的延迟钾通透性(PK),PK/PNa比值为0.32,这与大(25 - 30微米)蛙类纤维中的比值相似。这些结果与早期关于10 - 15微米欧洲林蛙纤维中存在较大延迟PK的证据一致;因此,最近关于PK大小依赖性差异的描述未得到证实。10 - 12微米两栖动物纤维中较大的PK(0.32 cm³s⁻¹×10⁻⁹)与12微米大鼠纤维中较小的PK(0.05 cm³ s⁻¹×10⁻⁹)形成对比。青蛙和蟾蜍纤维的节电容也更大(4 pF),但漏电导比大鼠纤维(1.4 pF和29 nS)小(18 nS)。这些差异可能与形态学证据有关,即与大鼠的节相比,两栖动物的节更开放,表面积更大。

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引用本文的文献

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Differential sensitivity of amphibian nodal and paranodal K+ channels to 4-aminopyridine and TEA.两栖动物结区和结旁区钾离子通道对4-氨基吡啶和四乙铵的敏感性差异
Experientia. 1987 Apr 15;43(4):405-8. doi: 10.1007/BF01940429.

本文引用的文献

1
ACCOMMODATION RELATED TO INACTIVATION OF THE SODIUM PERMEABILITY IN SINGLE MYELINATED NERVE FIBRES FROM XENOPUS LAEVIS.与非洲爪蟾单根有髓神经纤维钠通透性失活相关的适应性
Acta Physiol Scand. 1964 Aug;61:429-44.
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Potassium permeability in myelinated nerve fibres of Xenopus laevis.非洲爪蟾有髓神经纤维中的钾通透性。
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Steady state inactivation of sodium permeability in myelinated nerve fibres of Xenopus laevis.非洲爪蟾有髓神经纤维中钠通透性的稳态失活
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Sodium currents in the myelinated nerve fibre of Xenopus laevis investigated with the voltage clamp technique.用电压钳技术研究非洲爪蟾有髓神经纤维中的钠电流。
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Acta Physiol Scand. 1981 Oct;113(2):167-76. doi: 10.1111/j.1748-1716.1981.tb06878.x.
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Acta Physiol Scand. 1981 Oct;113(2):161-6. doi: 10.1111/j.1748-1716.1981.tb06877.x.
10
Size-dependent variation of nodal properties in myelinated nerve.有髓神经节段特性的大小依赖性变化。
Nature. 1981 Sep 24;293(5830):297-9. doi: 10.1038/293297a0.