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分离的脱髓鞘大鼠神经纤维的电学特性。

Electrical properties of isolated demyelinated rat nerve fibres.

作者信息

Brismar T

出版信息

Acta Physiol Scand. 1981 Oct;113(2):161-6. doi: 10.1111/j.1748-1716.1981.tb06877.x.

DOI:10.1111/j.1748-1716.1981.tb06877.x
PMID:7315446
Abstract

Isolated large rat nerve fibres with diphtheria toxin induced paranodal demyelination were investigated. These fibres had increased membrane time constant of the demyelinated nodal segment, related to a large increase in capacitance (5 to 50 times). The resting conductance was less increased (2 to 3 times), meaning that the internodal axolemma has considerably higher resting resistance than the nodal membrane. A large variation in action potential amplitude was found which was unrelated to the size of the nodal widening and the passive electrical properties.

摘要

对用白喉毒素诱导结旁脱髓鞘的大鼠分离大神经纤维进行了研究。这些纤维脱髓鞘结段的膜时间常数增加,这与电容大幅增加(5至50倍)有关。静息电导增加较少(2至3倍),这意味着结间轴膜的静息电阻比结膜高得多。发现动作电位幅度有很大变化,这与结增宽的大小和被动电学特性无关。

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