Breithardt G, Borggrefe M, Karbenn U, Ostermeyer J, Abendroth R R, Yeh H L, Seipel L
Z Kardiol. 1982 Jun;71(6):381-6.
19 patients with either previously documented sustained ventricular tachycardia (VT) (n = 16) or only inducible VT (n = 3, one of whom had recurrent syncope), due to previous myocardial infarction were studied pre- and postoperatively. Mean age was 53 +/- 6 years, 16 were male, 3 female. In all but one, VT could be induced preoperatively by programmed right ventricular stimulation. Late potentials (LP) were recorded at the end of or after the QRS-complex from the body surface using high-gain amplification and the signal averaging technique (RC-filter settings 100 to 300 Hz). Indication for surgery was either intractable VT or bypass grafting and/or aneurysmectomy. Preoperatively, mean duration of late potentials was 54 +/- 37.7 ms, mean amplitude was 12 +/- 14.0 mean V. Surgery was guided by epi- and endocardial mapping. In 14 cases endomyocardial encircling ventriculotomy was the main procedure, whereas in 5 patients only aneurysmectomy and bypass grafting were performed. Postoperatively, late potentials were no longer detectable in 12 cases, whereas in 6 of 7 cases there was a decrease in duration, but no essential change in amplitude. A postoperative electrophysiological study was performed in 18 cases. In those 12 patients with abolition of LPs, the maximal number of inducible ventricular echo beats using an extended stimulation program from three right ventricular sites, ranged between 1 and 5 in 9 cases, between 10 and 11 VE in 2 cases, whereas VT was induced in only 1 case. In 6 patients in whom LPs were still detectable, ventricular tachycardia could still be induced in 2 cases and a maximal response of ten echo beats was observed in another patient. Abolition of LP by surgery is closely related to the disappearance of the propensity to stimulus-induced VT. Thus the averaging technique may provide a non-invasive procedure to assess the successful outcome after operation for ventricular tachycardia. If, however, LPs are still present, this does not exclude successful surgical abolition of the propensity to ventricular tachycardia.
对19例既往有持续性室性心动过速(VT)记录(n = 16)或仅有可诱发性VT(n = 3,其中1例有反复晕厥)的患者进行了术前和术后研究,这些患者均因既往心肌梗死所致。平均年龄为53±6岁,男性16例,女性3例。除1例患者外,术前通过程控右心室刺激均可诱发VT。使用高增益放大和信号平均技术(RC滤波器设置为100至300Hz)从体表记录QRS波群终末或之后的晚电位(LP)。手术指征为顽固性VT或冠状动脉搭桥术和/或动脉瘤切除术。术前,晚电位平均持续时间为54±37.7ms,平均振幅为12±14.0μV。手术通过心外膜和心内膜标测引导。14例患者主要采用心内膜环形心室切开术,5例患者仅进行了动脉瘤切除术和冠状动脉搭桥术。术后,12例患者晚电位不再可检测到,而7例患者中有6例晚电位持续时间缩短,但振幅无显著变化。18例患者进行了术后电生理研究。在那些晚电位消失的12例患者中,使用来自三个右心室部位的扩展刺激程序,可诱发的最大室性回波搏动数在9例患者中为1至5次,2例患者中为10至11次室性回波,而仅1例患者诱发了VT。在仍可检测到晚电位的6例患者中,2例患者仍可诱发室性心动过速,另1例患者观察到最大反应为10次回波搏动。手术消除晚电位与刺激诱发VT倾向的消失密切相关。因此,平均技术可为评估室性心动过速手术后的成功结果提供一种非侵入性方法。然而,如果晚电位仍然存在,这并不排除手术成功消除室性心动过速倾向。