哒嗪核苷的构象：4-羟基-1-(β-D-呋喃核糖基)哒嗪-6-酮（3-脱氮-6-氮杂尿苷）的分子结构
Conformation of pyridazine nucleosides: the molecular structure of 4-hydroxy-1-(beta-D-ribofuranosyl)pyridazin-6-one (3-deaza-6-azauridine).
作者信息
Graves B J, Hodgson D J, Katz D J, Wise D S, Townsend L B
出版信息
Biochim Biophys Acta. 1978 Aug 23;520(1):229-32. doi: 10.1016/0005-2787(78)90023-0.
PMID:698230
Abstract
The glycosyl torsiona angle in 4-hydroxy-1-(beta-D-ribofuranosyl)-pyridazin-6-one (or 3-deaza-6-azauridine) is in the "high-anti" region. This is similar to the torsional angles observed for 6-azapyrimidine and 8-azapurine nucleosides, but in marked contrast to those found in uridine, 3-deazauridine and other pyrimidine nucleosides.
摘要
4-羟基-1-(β-D-呋喃核糖基)-哒嗪-6-酮（或3-脱氮-6-氮杂尿苷）中的糖基扭转角处于“高反式”区域。这与6-氮杂嘧啶和8-氮杂嘌呤核苷所观察到的扭转角相似，但与尿苷、3-脱氮尿苷和其他嘧啶核苷中的扭转角形成显著对比。
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