Kobayashi Y, Haruta T, Kuroki S, Ohkura K
Jpn J Antibiot. 1982 May;35(5):1207-11.
Some studies were carried out on the use of 9,3"-diacetylmidecamycin (MOM) dry syrup, a new macrolide antibiotic preparation, in the treatment of children. The results are summarized below. 1) A single oral dose of 10 mg/kg of the MOM dry syrup was administered to 1 child at 2 hours after a meal. The peak concentration of the antibiotic in the blood was 0.88 micrograms/ml and occurred at 1 hour after administration. At 2 hours the concentration had fallen to 0.59 microgram/ml, and after 4 hours the blood level was already below the minimum detectable concentration (0.5 microgram/ml). During the first 6 hours after the administration, 6.7% of the MOM was recovered in the urine. 2) The MOM dry syrup was orally administered to 4 pneumonia patients (including 2 cases of mycoplasmal pneumonia) for 7 days at a daily dosage of 15.2--20.5 mg/kg (divided into 3 equal doses). The therapeutic results were excellent in 2 cases, good in 2 cases and poor in none. 3) No side effects such as exanthema were observed to occur. In 1 case only, there was a mild and temporary elevation in the laboratory test values for total bilirubin, GOT and GTP. 4) All 4 of the pneumonia patients found the MOM dry syrup to be easy to ingest. The taste and odor of this antibiotic preparation were judged to be sufficiently palatable to permit convenient use in the treatment of children.
对一种新型大环内酯类抗生素制剂9,3"-二乙酰麦迪霉素（MOM）干糖浆用于儿童治疗进行了一些研究。结果总结如下。1）在饭后2小时给1名儿童口服单剂量10mg/kg的MOM干糖浆。抗生素在血液中的峰值浓度为0.88微克/毫升，于给药后1小时出现。2小时时浓度降至0.59微克/毫升，4小时后血药水平已低于最低检测浓度（0.5微克/毫升）。给药后的前6小时内，6.7%的MOM在尿液中回收。2）对4例肺炎患者（包括2例支原体肺炎）口服MOM干糖浆，每日剂量为15.2 - 20.5mg/kg（分3等份），持续7天。治疗结果2例为优，2例为良，无差的病例。3）未观察到诸如皮疹等副作用发生。仅1例患者的总胆红素、谷草转氨酶和谷丙转氨酶实验室检测值有轻度且短暂的升高。4）4例肺炎患者均认为MOM干糖浆易于服用。这种抗生素制剂的味道和气味被判定为足够可口，便于用于儿童治疗。
