Synthesis and biological evaluation of some 5-aryl-2-amino-1,3,4-oxa(thia)diazoles.

Three series of 5-aryl-2-amino or 2-amino substituted 1,3,4-oxadiazoles (IV-XVIII) were prepared together with the corresponding series of the analogous 5-aryl-2-amino-1,3,4-thiadiazoles (XIX-XXXIII). The purpose of this work is two-fold: to study their pharmacological action in relation to the substituents bound to the positions -2 and -5, and to observe whether the isosteric substitution of the oxygen of he oxadiazolic nucleus with the sulfur leading to a thiadiazolic nucleus causes any activity variation. The AA. report and discuss the results obtained studying the antifungal as well as the antiinflammatory and antipyretic activity of the synthetized compounds.