[Stomach tolerance of non-steroid anti-rheumatic agents. Studies on gastric irritation caused by carprofen in comparison with acetylsalicyclic acid, indomethacin, piroxicam, and diclofenac].

This is the report of a study on the new non-steroidal antiphlogistic substance Carprofen. In this comparative study Carprofen was tested versus acetylsalicylic acid, Indomethacin, Piroxicam and Diclofenac using the gastric irritation model, by means of a non invasive technique of measuring the gastric transmural potential difference. The study was carried out on a group of 10 healthy male volunteers and led to the following results: The most marked irritation was observed after administration of acetylsalicylic acid followed by Indomethacin. The lowest values of the relevant parameters concerning the gastric irritation were measured after the administration of Carprofen. The differences between acetylsalicylic acid and Indomethacin, and between Indomethacin and the other nonsteroidal substances which were tested could be proven statistically. There was no difference between Piroxicam, Diclofenac and Carprofen that could be proven statistically, nevertheless Carprofen showed the lowest irritation potency of the three non-steroidal antiphlogistics tested.