Lewis A B, Nestor L, Dahms B, Platzker A C
Biol Neonate. 1978;34(1-2):97-104. doi: 10.1159/000241112.
The cardiovascular responses to autonomic blockade were investigated in 15 late-gestation fetal lambs in utero. 4 animals had normal brains and 11 had hydranencephalic-like cerebral injury secondary to bilateral carotid artery obstruction (BCO). Following atropine administration, heart rate increased only 0.7 +/- 0.7% in the BCO lambs compared to 25.7 +/- 5.2% in the controls. alpha-Blockade with phentolamine resulted in a small decrease in systolic (2.2 +/- 0.8%) and diastolic (1.8 +/- 1.4%) blood pressure, and beta-blockade with propranolol produced a small decrease in heart rate (2.5 +/- 0.8%) as compared to control fetuses. Post mortem examination revealed extensive destruction of the cerebrum but normal hypothalamus and brain stem. These data suggest that supramedullary modification of autonomic cardiovascular control involves the cerebrum.
在15只妊娠晚期的子宫内胎羊中研究了自主神经阻滞对心血管系统的影响。4只动物脑部正常，11只因双侧颈动脉阻塞（BCO）继发类似积水性无脑的脑损伤。给予阿托品后，BCO组胎羊心率仅增加0.7±0.7%，而对照组为25.7±5.2%。酚妥拉明进行α受体阻滞导致收缩压（2.2±0.8%）和舒张压（1.8±1.4%）略有下降，普萘洛尔进行β受体阻滞导致心率与对照胎儿相比略有下降（2.5±0.8%）。尸检显示大脑广泛破坏，但下丘脑和脑干正常。这些数据表明，自主神经对心血管系统控制的延髓以上调节涉及大脑。
