Lim S D, Woo C S, Youn J I, Kim Y W, Kim D I, Fusaro R M
Int J Dermatol. 1982 Oct;21(8):458-64. doi: 10.1111/j.1365-4362.1982.tb03182.x.
The authors quantitated T-rosette-forming cell (TRFC) and T-cell subsets (T mu, T gamma) in the peripheral blood of twenty patients with lepromatous leprosy. The results obtained in their studies are as follows: (1) They reconfirmed the low levels of TRFC in patients with lepromatous type of leprosy; (2) T-cell subsets, both T mu (helper) and T gamma (suppressor) cells, showed lower levels in all patients with lepromatous leprosy than mean values of normal healthy controls; (3) The degree of decreased levels of T mu cells (96%) was more severe than other parameters TRFC (70%) and T gamma cells (47%) in all patients with lepromatous leprosy; and (4) It may be concluded that the alteration of the T-cell subset, T mu-cells, reflects a more fundamental abnormality than TRFC aberration in demonstrating the impairment of cell-mediated immunity in patients with lepromatous leprosy.
作者对20例瘤型麻风患者外周血中的T玫瑰花结形成细胞（TRFC）和T细胞亚群（Tμ、Tγ）进行了定量分析。他们的研究结果如下：（1）再次证实瘤型麻风患者的TRFC水平较低；（2）所有瘤型麻风患者的T细胞亚群，即Tμ（辅助性）细胞和Tγ（抑制性）细胞，均低于正常健康对照的平均值；（3）在所有瘤型麻风患者中，Tμ细胞水平下降的程度（96%）比其他参数TRFC（70%）和Tγ细胞（47%）更严重；（4）可以得出结论，在显示瘤型麻风患者细胞介导免疫受损方面，T细胞亚群Tμ细胞的改变比TRFC异常反映出更根本的异常。
