[Effect of marrow cavity curettage on bone marrow stromal cell precursors].

Changes in the number of bone marrow stromal precursor cells of guinea pigs after the bone marrow curettage was studied by cloning in monolayer cultures in vitro. About half of the colony-forming units (CEU-F) is extracted during curettage. Later the number of CFU-F in the curetted bone marrow continues to fall, reaching its minimum in 12 hours. Regeneration begins after 24 hours, and on the 7th--12th day the CFU-F content in the curetted bone marrow reacts the normal level; by the 20th day the number of CFU-F exceeded the normal 2.5 times. The CFU-F content in the contralateral bones of donors exceeded their normal content (at periods from 6 hours to 20 days) 2--2 1/2-fold.