Pal'tsyn A A, Badikova A K, Kolokol'chikova E G, Sanovich E Ia
Biull Eksp Biol Med. 1978 Sep;86(9):367-70.
The number of nucleoli and the structure of nucleolus-associated chromatin (determined by the number of perinucleolar chromocentres) was investigated in two groups of mice. The first group was control, and the second one--experimental, given CCl4 injections once a week, for one year. A gradual increase of the number of nucleoli and chromocentres bound with nucleoli was revealed with ageing in control mice. In the experimental group both indices quickly reached the maximum which was equal or even higher than in old control mice. The subsequent development of the pathological process failed to alter these indices. Possible mechanisms limiting the range of the mentioned changes of the nuclei are discussed.
在两组小鼠中研究了核仁数量以及核仁相关染色质的结构（由核仁周围染色中心的数量确定）。第一组为对照组，第二组为实验组，每周注射一次四氯化碳，持续一年。在对照小鼠中发现，随着年龄增长，核仁数量以及与核仁结合的染色中心数量逐渐增加。在实验组中，这两个指标迅速达到最大值，该最大值等于甚至高于老年对照小鼠。病理过程的后续发展并未改变这些指标。讨论了限制上述细胞核变化范围的可能机制。
