Wharton W, Walker E, Stewart C C
Adv Exp Med Biol. 1982;155:249-60. doi: 10.1007/978-1-4684-4394-3_25.
The evidence reviewed here indicates that macrophages, either acting alone or in concert with other cells, influence the proliferation of multiple types of cells. Most of the data indicate that these effects are mediated by soluble macrophage-elaborated products (probably proteins) although the role of direct cell-to-cell contacts cannot be ruled out in all cases. A degree of success has been achieved on the biochemical characterization of these factors, but such work has been hampered by the factors low specific activity in conditioned medium and the lack of rapid, specific assays. It is our belief that understanding the growth-regulating potential of macrophages is an important and needed area of research.
此处回顾的证据表明，巨噬细胞无论是单独作用还是与其他细胞协同作用，都会影响多种类型细胞的增殖。大多数数据表明，这些效应是由巨噬细胞分泌的可溶性产物（可能是蛋白质）介导的，尽管在所有情况下都不能排除直接细胞间接触的作用。在这些因子的生化特性表征方面已经取得了一定程度的成功，但这项工作受到条件培养基中因子比活性低以及缺乏快速、特异性检测方法的阻碍。我们认为，了解巨噬细胞的生长调节潜能是一个重要且必要的研究领域。
