睾丸间质细胞在体外非特异性抑制淋巴细胞增殖：对睾丸作为免疫特惠部位的意义。

Leydig cells nonspecifically suppress lymphoproliferation in vitro: implications for the testis as an immunologically privileged site.

作者信息

Born W, Wekerle H

出版信息

Am J Reprod Immunol (1980). 1982 Dec;2(6):291-5. doi: 10.1111/j.1600-0897.1982.tb00195.x.

DOI:10.1111/j.1600-0897.1982.tb00195.x

Abstract

We have studied the influence of mouse testis cells on unstimulated lymphoproliferation; on allogeneic mixed lymphocyte reaction; and on concanavalin A-stimulated, phytohemagglutinin-stimulated, or lipopolysaccaride-stimulated responses in vitro. Co-culture with highly enriched irradiated (2000 R) Leydig cells (LC) led in each case to a considerable reduction of 3H TdR uptake. Prolonged tissue graft survival times suggest that the testis is an immunologically privileged site. This may be explained by an immune-suppressive function of LC in vivo. LC are also capable of selectively binding lymphoid and myeloid cells to their surface. This capacity, accompanied by a suppression of immune reactivity in situ, may play a role in cases of testicular relapse observed in acute leukemia.

摘要

我们研究了小鼠睾丸细胞对未刺激的淋巴细胞增殖、对同种异体混合淋巴细胞反应以及对体外伴刀豆球蛋白A刺激、植物血凝素刺激或脂多糖刺激反应的影响。与高度富集的经照射（2000拉德）的睾丸间质细胞（LC）共培养，在每种情况下均导致³H胸苷摄取量显著降低。组织移植存活时间延长表明睾丸是一个免疫特惠部位。这可能是由于LC在体内具有免疫抑制功能。LC还能够将淋巴细胞和髓细胞选择性地结合到其表面。这种能力，伴随着原位免疫反应性的抑制，可能在急性白血病中观察到的睾丸复发情况中起作用。