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眼部弓形虫病的免疫学

Immunology of ocular toxoplasmosis.

作者信息

Wakefield D, Penny R

出版信息

Aust J Ophthalmol. 1982 Nov;10(4):277-81. doi: 10.1111/j.1442-9071.1982.tb01630.x.

DOI:10.1111/j.1442-9071.1982.tb01630.x
PMID:6984328
Abstract

Toxoplasma gondii, due to its ability to escape and modify the normal immune response, is able to survive within the retina indefinitely with the production of an occasional acute inflammatory response. The cellular immune system is mainly responsible for limiting infection. Diagnosis is based on clinical features coupled with measurements of antibody response (systemic and ocular) and cell mediated immunity. The treatment of toxoplasma chorioretinitis when indicated should be specific and immunosuppressive agents should only be used in conjunction with antibiotics to avoid dissemination of the organism.

摘要

由于能够逃避和改变正常免疫反应,弓形虫能够在视网膜内存活,偶尔引发急性炎症反应。细胞免疫系统主要负责限制感染。诊断基于临床特征,结合抗体反应(全身和眼部)测量以及细胞介导免疫检测。有指征时,弓形虫脉络膜视网膜炎的治疗应具有特异性,免疫抑制剂仅应与抗生素联合使用,以避免病原体扩散。

相似文献

1
Immunology of ocular toxoplasmosis.眼部弓形虫病的免疫学
Aust J Ophthalmol. 1982 Nov;10(4):277-81. doi: 10.1111/j.1442-9071.1982.tb01630.x.
2
Intraocular anti-Toxoplasma gondii IgA antibody production in patients with ocular toxoplasmosis.眼部弓形虫病患者眼内抗弓形虫IgA抗体的产生
Am J Ophthalmol. 1999 Mar;127(3):294-300. doi: 10.1016/s0002-9394(98)00337-7.
3
Differences between intraocular and serum antibody responses in patients with ocular toxoplasmosis.眼部弓形虫病患者眼内抗体反应与血清抗体反应的差异。
Am J Ophthalmol. 1998 Nov;126(5):698-706. doi: 10.1016/s0002-9394(98)00116-0.
4
Specific IgM, IgG and IgG1 directed against Toxoplasma gondii detected by flow cytometry and their potential as serologic tools to support clinical indirect fundoscopic presumed diagnosis of ocular disease.通过流式细胞术检测到的针对刚地弓形虫的特异性IgM、IgG和IgG1及其作为血清学工具支持眼部疾病临床间接检眼镜推测诊断的潜力。
J Immunol Methods. 2015 Feb;417:97-106. doi: 10.1016/j.jim.2014.12.012. Epub 2014 Dec 17.
5
Serologic evaluation of patients with primary and recurrent ocular toxoplasmosis for evidence of recent infection.对原发性和复发性眼部弓形虫病患者进行血清学评估,以寻找近期感染的证据。
Am J Ophthalmol. 1999 Oct;128(4):407-12. doi: 10.1016/s0002-9394(99)00266-4.
6
Congenital toxoplasma chorioretinitis transmitted by preconceptionally immune women.孕前免疫女性传播的先天性弓形虫脉络膜视网膜炎
Br J Ophthalmol. 1998 Dec;82(12):1444-5. doi: 10.1136/bjo.82.12.1444.
7
Analysis of aqueous humor in ocular toxoplasmosis: detection of low avidity IgG specific to Toxoplasma gondii.眼部弓形虫病房水分析:检测针对刚地弓形虫的低亲和力IgG
Appl Parasitol. 1994 Feb;35(1):1-7.
8
The aetiology of ocular toxoplasmosis in Melbourne.墨尔本眼部弓形虫病的病因
Aust N Z J Ophthalmol. 1993 Feb;21(1):29-30. doi: 10.1111/j.1442-9071.1993.tb00126.x.
9
Specific diagnosis of toxoplasmic chorioretinitis by demonstration of intraocular toxoplasma IgG antibodies.通过检测眼内弓形虫IgG抗体对弓形虫性脉络膜视网膜炎进行特异性诊断。
Prog Clin Biol Res. 1985;163B:339-41.
10
Toxoplasma infection in healthy persons and in patients with HIV or ocular disease.
Southeast Asian J Trop Med Public Health. 1995 Dec;26(4):655-8.

引用本文的文献

1
Detection of specific immunoglobulin E in patients with toxoplasmosis.弓形虫病患者中特异性免疫球蛋白E的检测
J Clin Microbiol. 1990 Aug;28(8):1739-43. doi: 10.1128/jcm.28.8.1739-1743.1990.