Dyck P J, Karnes J, Sparks M, Low P A
Electroencephalogr Clin Neurophysiol Suppl. 1982;36:39-55.
An extensive morphometric evaluation of the number, density and diameter distribution of myelinated fibres (MFs) of different nerves, of different proximal-distal levels of nerves, and of different species is reported. The methodology used provides reliable estimates of number and size because of the use of optimal histological techniques, semi-thin sections, careful systematic sampling, nonsubjective evaluation of transverse MF profiles using computerized imaging and evaluation of large numbers of MFs and nerves. The non-MF percentage of endoneurial area was also measured as an index of the amount of nerve microenvironment. We have confirmed that the MF composition is quite variable between nerves, between levels of nerves, and between species. In general the density of MFs is lower in the nerves of man than in the nerves of other animals evaluated, in distal than in proximal levels, in old age and in disease. Although increased endoneurial fluid may play a role in resistance to ischaemic block it appears that the intrinsic metabolic properties of the neural tissue itself are most important.
本文报告了对不同神经、神经不同近远端水平以及不同物种的有髓纤维（MFs）数量、密度和直径分布进行的广泛形态计量学评估。由于采用了最佳组织学技术、半薄切片、仔细的系统抽样、使用计算机成像对横向MF轮廓进行非主观评估以及对大量MF和神经进行评估，所使用的方法能够提供可靠的数量和大小估计。神经内膜面积的非MF百分比也作为神经微环境量的指标进行了测量。我们已经证实，MF组成在神经之间、神经水平之间以及物种之间存在很大差异。一般来说，人类神经中的MF密度低于其他评估动物的神经，远端低于近端，老年和疾病状态下也较低。尽管神经内膜液增加可能在抵抗缺血性阻滞中起作用，但神经组织本身的内在代谢特性似乎最为重要。
